Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment, engineered to retain neurotropic activity while removing the corticotropic effects of the parent hormone. For research teams studying neuroprotection, neurotrophic signaling, and cognitive-related pathways, it is a widely referenced tool compound with a substantial preclinical literature. Puritide Research supplies Semax as a high-purity, research-use-only material, synthesized for in vitro and animal-model work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.
Product Specifications
- Application
- Neuroprotection, neurotrophic signaling, and cognitive pathway research
- Appearance
- Solid, white lyophilized powder in a sealed glass vial
- Chemical Formula
- C37H51N9O10S
- PubChem SID
- 9941958
- CAS Number
- 80714-61-0
- Molecular Weight
- ~813.93 g/mol
- Synonyms
- Semax, ACTH(4-10) analog, Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
- Storage
- Store at ≤25°C, sealed, away from heat, light, and moisture. For extended storage, keep lyophilized and refrigerated or frozen.
What Is Semax?
Semax is a synthetic heptapeptide with the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP). It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as an analog of the N-terminal ACTH(4-10) fragment of adrenocorticotropic hormone. The native C-terminal Arg-Trp-Gly tripeptide is replaced with Pro-Gly-Pro, a substitution reported to confer resistance to plasma peptidases while eliminating corticotropic activity and preserving neurotropic activity.
In experimental settings, Semax is studied for its influence on neurotrophic factor expression, neuroprotective pathways, and cognitive-related endpoints. Researchers use it to explore BDNF/TrkB signaling, monoaminergic systems, and peptide pharmacology within controlled cell-culture and animal models.
Present understanding derives from in vitro assays and animal models, together with clinical research conducted primarily in Russia. Findings should be interpreted within their experimental context and not treated as established outcomes. Puritide Research supplies Semax strictly for laboratory use; it is not approved for human or veterinary application.
Puritide Research supplies Semax strictly for laboratory research use. Not for human or veterinary use.
Research Use Only
