Research Use Only

Lab results

Certificate of Analysis 99.96%Endotoxin Report PASS Verify this lotAuthentic →

Research Use Only

These compounds are NOT intended for human consumption, clinical use, or veterinary applications. We are not affiliated with any pharmaceutical companies or their commercial medications. By placing an order, you certify these materials will be used exclusively for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

Longevity / mitochondrial

PNC-27

Name: PNC-27 10ml
Brand: Puritide Research
SKU: PR-PNC27
Price: 45.00 USD
Availability: InStock

PR-PNC27 · ≥99%

PNC-27 is a chimeric 32-residue peptide combining a fragment of the p53 tumor-suppressor protein with a cell-penetrating leader sequence.

Quantity & savings

PNC-27

Research use only

10ml · $45.00

✓Lyophilized and sealed under sterile, controlled conditions
✓Purity ≥99%, mass-spectrometry and analytical HPLC verified
✓Fully traceable from first synthesis to sealed vial
✓Certificate of analysis (CoA) included with every vial

Ships cold-safe · discreet packaging · tracked delivery.

Lab results

Certificate of Analysis 99.96%Endotoxin Report PASS Verify this lotAuthentic →

Research Use Only

About PNC-27

PNC-27 is a chimeric 32-residue peptide combining a fragment of the p53 tumor-suppressor protein with a cell-penetrating leader sequence. It is studied as a research tool for HDM-2 (MDM2) binding, membrane-pore formation, and selective cancer-cell interaction in cell-culture models. Puritide Research supplies PNC-27 as a high-purity, research-use-only solution, prepared for in vitro work and backed by third-party-verified certificates of analysis so your data rests on consistent, documented quality.

Available Sizes

›PNC-27 10 mL

Product Specifications

Application: HDM-2 (MDM2) binding and membrane-interaction research
Appearance: Clear, sterile-filtered solution supplied in a sealed vial
Chemical Formula: C188H293N53O44S
Molecular Weight: ~4031.72 g/mol
Synonyms: PNC-27, p53-penetratin chimeric peptide, MRP-p53 (12-26) peptide, HDM-2-binding peptide
Storage: Store refrigerated (2-8°C) protected from light; for extended storage keep frozen. Avoid repeated freeze-thaw cycles.

Some analytical parameters have not yet been formally characterized for this research compound.

What Is PNC-27?

PNC-27 is a chimeric peptide of 32 amino acids that fuses residues 12-26 of the HDM-2-binding domain of the human p53 tumor-suppressor protein to a membrane-residency (cell-penetrating) leader sequence. This design pairs an HDM-2 recognition element with a sequence that promotes transport across cell and mitochondrial membranes.

In experimental settings, PNC-27 is studied for its reported ability to bind HDM-2 (the human MDM2 homolog) associated with the plasma membrane of certain transformed cell lines, where the interaction is described in the literature as inducing selective membrane-pore formation and cell lysis. It is supplied by Puritide Research as a ready-to-use liquid solution rather than a lyophilized powder.

Present understanding derives from in vitro assays and cell-culture models. Findings should be interpreted within their experimental context and not treated as established clinical outcomes. Puritide Research supplies PNC-27 strictly for laboratory use; it is not approved here for human or veterinary application.

Puritide Research supplies PNC-27 strictly for laboratory research use. Not for human or veterinary use.

5-Amino-1MQ

Longevity / mitochondrial

5-Amino-1MQ is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme increasingly studied for its role in cellular energy metabolism.

Certificate of AnalysisLOT #AMI152503-57V · 99.83%PASS

$175.00

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